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Denis Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory who led the research, said: “It’s the cells without CD45 that are the precursors for pancreatic islets. They have a distinct function that has not previously been identified for the spleen.”
Dr David Nathan, director of the hospital’s Diabetes Center, added: “These exciting findings in a mouse model of Type 1 diabetes suggest that patients who are developing this disease could be rescued from further destruction of their insulin-producing cells.
“In addition, patients with fully established diabetes possibly could have their diabetes reversed.”
Dr Eleanor Kennedy, research director for Diabetes UK , said “The initial results of this research are potentially very exciting for people with diabetes. Reversing the onset of Type 1 diabetes by turning adult precursor cells from the spleen into insulin-producing cells is a new approach.